Medicinal Chemistry Services

• • Hit Identification
    • Library synthesis
    • Focused synthesis 
  • Lead Generation
  • Lead Optimization
  • Pre-selected compounds synthesis and AMES batches
  • Analytical of Pre-selection compounds

Library Design & Synthesis

Target based 

• • Kinases / GPCRs / Ion – channel / Nuclear Receptors and other enzymes
  • Designed Molecules are filtered on the basis of Lipinski Filters
  • Segregated as Drug-like, Lead-like, etc.

Fragment based 

• • Libraries of small molecules (Molecular weight < 300)
  • Building molecules and Pharmacophore  generation

Advance Chemical Analoging Approach

Natural product based 

• • Libraries from existing Natural Products
  • Scaffolds inspired from existing Natural Products (Linear Hybrids, Diversity oriented synthesis of Natural Product-inspired Scaffolds)

De Novo libraries

• • Libraries on novel scaffolds

Computational Chemistry Services

Structure-based Methods

• Small molecule library screening  using docking and scoring
• Fragment-based design (De novo compound design)
• Structure-based pharmacophore modeling and library screening 
• Focused library design using protein and  ligand complex

Ligand-based Methods

• Feature, shape and field-based  pharmacophore models 
• QSAR models and virtual library screening
• Scaffold hopping  and bioisoster replacement 
• Virtual library screening using ligand based models
• Focused library generation (De novo scaffold design) & enumeration

Cheminformatics Techniques for Compound Selection

• Similarity & diversity analysis
• Physicochemical  property filters
• ~5MM virtual compounds from 18 vendor companies 
• Novelty analysis (IP potential)

Analytical Services

Capabilities

• • Routine Assay
  • Raw material characterization as per latest Pharmacopoeia (USP, BP, EP, IP, JP)
  • Method development as per ICH guidelines
  • Method validation as per ICH guidelines
  • Impurity isolation and characterization
  • Trace metal analysis using AAS and ICP-MS techniques
  • Organic Volatile Impurities and Residual Solvents as per USP
  • Heavy metals
  • Extractables and Leachables analysis

Process R&D and Custom Synthesis

We can do large scale non-GLP synthesis

• • Route design and optimization
  • Scale-up of multi-step procedures up to kilogram quantities
  • Consistent batches in grams 
  • Manufacturing of pharmaceutical raw materials and advanced intermediates
  • Identify Quality Attributes, Critical Quality Attributes
  • Risk assessment, Process Robustness
  • Identify potentially Critical Process Parameters, Solvent, temperature, addition etc.
  • Experimental data and scientific discussion, clarity in process, in-process controls
  • Analytical studies, Impurity profiling and cause of formation, controllable process Tech transfer to kilo lab or pilot plant 
  • Large scale purifications

Biology services

We can do large scale non-GLP synthesis

• • Bioinformatics Consulting
  • Invivo Pharmacokinetics
  • Invitro stability studies
  • Invitro ADMET
  • In vivo non-glp exploratory toxicology
  • Drug Permeation and Transport
  • Drug Drug interactions
  • Biomarker development
  • Cytogenetics
  • Microbiology (Strain development)
  • Research  methodology development